AD Quality Auto 360p 720p 1080p Top articles1/5READ MOREChargers go winless in AFC West with season-ending loss in Kansas CityThe widely used process has helped scientists use mice to study heart disease, diabetes, cancer, cystic fibrosis and other diseases. The prize is shared by Mario R. Capecchi, 70, of the University of Utah in Salt Lake City; Oliver Smithies, 82, a native of Britain now at University of North Carolina in Chapel Hill; and Sir Martin J. Evans, 66, of Cardiff University in Wales. The Nobel is a particularly striking achievement for Capecchi. A native of Italy, he was separated from his mother at age 4 when she was taken to the Dachau concentration camp as a political prisoner during World War II. For four years, Capecchi lived on the street or in orphanages, “and most of the time hungry,” he recalled in a University of Utah publication in 1997. Malnutrition sent him to a hospital where his mother found him on his 9th birthday. Within two weeks they left for the United States, where he went to school for the first time, starting in third grade despite not knowing English. The three scientists were honored for a technique called gene targeting, which lets scientists deactivate or modify particular genes in mice. That in turn lets them study how those genes affect health and disease. HONORS: The prize in medicine goes to three scientists from the U.S. and Great Britain. By Karl Ritter and Matt Moore THE ASSOCIATED PRESS STOCKHOLM, Sweden – Two American scientists and a Briton won the 2007 Nobel Prize in medicine on Monday for groundbreaking discoveries that led to a powerful technique for manipulating mouse genes. To use this technique, researchers introduce a genetic change into mouse embryonic stem cells. These cells are then injected into mouse embryos. The mice born from these embryos are bred with others to produce offspring with altered genes. The first mice with genes manipulated in this way were announced in 1989. More than 10,000 different genes in mice have been studied with the technique. 160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set!