Blocking activity of plasma protein can be possible way to protect against

first_img Source:https://www.umu.se/en/news/blockering-av-protein-mojlig-vag-hindra–biverkningar-_7287920/ Reviewed by James Ives, M.Psych. (Editor)Nov 20 2018It is possible to prevent certain injuries that can occur in radiation therapy against cancer. By blocking the activity of a plasma protein during and immediately after radiation, the patient can be protected against injury. This is shown in a new doctoral thesis at Umeå University, Sweden.”Injury in radiation therapy can be painful and seriously impair the patient’s quality of life. Therefore, it is important to find ways to treat or, even better, prevent the damage,” says Mahsa Fallah, PhD student at the Department of Medical Biochemistry and Biophysics at Umeå University.Related StoriesUsing NMR to Study Protein Structure, Dynamics and MechanismsMother calls for protein shake regulation after daughter diesSorting protein in neurons protects against neurodegenerative disordersThe most common skin effect in radiation therapy against cancer is skin redness, erythema, which affects nine out of ten radiation-treated patients. The rancidity can develop into skin flaking, desquamation. Other areas where radiation effects occur are the gastrointestinal tract and bone marrow.Today, wounds caused by radiation are being treated locally with dressing, antibiotics, cortisone, or in severe cases through skin transplantation.In her doctoral thesis, Mahsa Falla shows the importance of the plasma protein plasminogen for the development of inflammation and damage after radiation. In studies mice that lack plasminogen have been shown to be resistant to radiation damage. Even in mice that had plasminogen, the damage could greatly be reduced by treating the patient with a substance, tranexamic acid, which inhibits the activation of plasminogen.”Overall, studies indicate that it is advisable to prevent radiation damage to the skin by treating the cancer patient with tranexamic acid. It is worth researching if the same strategy could also be used to protect internal organs from radiation damage,” says Mahsa Fallah. last_img read more

Scientists identify potential target for Parkinsons treatment

first_imgVolpicelli-Daley, in concert with biochemist Nunilo Cremades, Ph.D., at the University of Zaragoza, Spain, examined three structural forms of alpha-synuclein in animal models. There has been major debate in the field whether alpha-synuclein oligomers -; several alpha-synuclein molecules that associate together, or fibrils -; with a defined protein structure called amyloid, are most responsible for toxicity in Parkinson’s disease.Related StoriesNeural pathways explain the relationship between imagination and willingness to helpAn active brain and body associated with reduced risk of dementiaMother calls for protein shake regulation after daughter dies”Our findings indicate that the form most toxic to neurons was a structure referred to as beta-sheet fibrillar fragments,” Volpicelli-Daley said. “This is a form of alpha-synuclein that makes overlapping sheets of the protein, which subsequently develop into long filaments. The filaments can then break into smaller fragmented pieces. We hypothesize that the smaller fibrillar fragments are the most toxic to neurons because they are able to attract and corrupt normal alpha-synuclein, causing it to form aggregates that spread throughout the neuron, causing damage to the brain.”The team suggests that the damage caused by the fragments and subsequent aggregation of normal alpha-synuclein is responsible for a reduction in the chemical messenger dopamine, which is essential for coordinated movement. Loss of dopamine is well-associated with Parkinson’s disease.The team also showed that oligomers had some toxic effects on brain cells, but not to the same degree as the fibril fragments.”All this suggests that beta-sheet fibrillar fragments specifically should be a target for development of therapeutic strategies, such as immunotherapy, that might reduce the formation and propagation of this form of alpha-synuclein,” Volpicelli-Daley said. “This strategy may work to slow or stop the progression of Parkinson’s and other disorders that involve alpha-synuclein, such as Lewy body dementia.”Source:University of Alabama at BirminghamJournal reference:Volpicelli-Daley, L. et al. (2019) Defining α-synuclein species responsible for Parkinson disease phenotypes in mice. Journal of Biological Chemistry. doi.org/10.1074/jbc.RA119.007743. We’ve long known that the aggregation or clumping of alpha-synuclein plays an important role in diseases such as Parkinson’s. Our funding agencies – the Michael J. Fox Foundation and support from the UAB Udall Center for Excellence in Parkinson’s Disease Research, have made study of alpha-synuclein a priority. We think that, by preventing alpha-synuclein from forming aggregates, we can prevent progression of the disease.”Laura Volpicelli-Daley, Ph.D., assistant professor in the Department of Neurology in the School of Medicine Reviewed by Kate Anderton, B.Sc. (Editor)Jun 12 2019An international research team led by scientists at the University of Alabama at Birmingham has identified a potential target for therapeutics that might help slow the progression of Parkinson’s disease.In findings published online in the Journal of Biological Chemistry, the researchers compare different forms of alpha-synuclein and specifically point to beta-sheet fibrillar forms of the alpha-synuclein protein as a promising target.Alpha-synuclein is a protein found in the human brain. While its role in a healthy brain is not completely understood, science does know that, in conditions such as Parkinson’s disease, Lewy body dementia and Alzheimer’s disease, alpha-synuclein clumps into aggregates that damage neurons. The UAB-led research team looked at several different structural forms of alpha-synuclein to determine which was most responsible for damage to the brain, and thus the most likely target for therapeutic intervention.last_img read more

AkzoNobel splashes out as Q1 profits paint rosy picture

Explore further © 2018 AFP This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Leading global paintmaker AkzoNobel Tuesday posted rising first quarter profits and after a turbulent year in 2017 hailed its transformation into a focused paints company. AkzoNobel to sell chemicals arm for 10.1 bn euros Last month the company announced it was selling its chemicals arm to US-based investors Carlyle Group and Singapore’s GIC for 10.1 billion euros ($12.6 billion), seeking to restore investor confidence in the Dutch giant.That was “a key milestone” in the company’s history, said chief executive Thierry Vanlancker, revealing profits for the first three months rose 5.0 percent on the same period in 2017 to hit 253 million euros.Sales however dropped some 8.0 percent to 2.2 billion euros, hit mainly by fluctuating currencies. Volume was also hit as “headwinds continue for marine and protective coatings,” said Vanlancker.The manufacturer of such household paint brands as Dulux and Trimetal, AkzoNobel last year decided to divest its chemicals arm as it fended off an increasingly hostile takeover bid by US-based rival PPG.After making three offers, PPG eventually dropped its efforts in mid-2017, which would have valued the Dutch company at 26.9 billion euros.The sale to Carlyle Group and Singapore’s GIC is due to be completed towards the end of 2018, with the net proceeds after deductions of about 7.5 billion euros due to be distributed to shareholders.”The transformation is gaining momentum and we are on track for delivering 15 percent return on sales by 2020,” said Vanlancker. Citation: AkzoNobel splashes out as Q1 profits paint rosy picture (2018, April 24) retrieved 18 July 2019 from https://phys.org/news/2018-04-akzonobel-splashes-q1-profits-rosy.html AkzoNobel, the world’s leading paintmaker, owns brands such as Dulux and Trimetal read more

Mexico acknowledges banks were hacked losses unknown

Explore further © 2018 The Associated Press. All rights reserved. Mexico established a one-day waiting period on electronic money transfers of over $2,500 in the wake of a hacking attack that may have taken as much as $20 million from several Mexican banks. Citation: Mexico acknowledges banks were hacked; losses unknown (2018, May 15) retrieved 18 July 2019 from https://phys.org/news/2018-05-mexico-acknowledges-banks-hacked-losses.html It was the latest in a string of embarrassments for the Mexican banking system, which has seen slowdowns in e-payment, debit card transactions and transfers since late April.The head of the country’s central bank, Alejandro Diaz de Leon acknowledged late Monday that a “cyberattack” was involved in shadowy transfers of between $18 million and $20 million.The central bank issued a memo Monday saying banks could opt to immediately pay out transfers for customers they know and trust, but would impose a one-day wait period for others.The head of the country’s bankers’ association told local media Tuesday that the hackers had apparently duplicated valid settlement payments between banks, with one copy going to the intended recipient and the other going to account set up by hackers.Few expected authorities to be so unprepared. Security breakdowns were first detected on April 27, but by Monday, authorities were still not sure how much had been taken. They said some of the fake transfers were caught before they could go through.But it was also revealing that the central bank did not have a cybersecurity division until Tuesday, when one was created by decree.Mexican depositors won’t be affected, but the banks themselves could take a hit on the missing money. Hackers divert funds from Mexico banks, amount unclear: official This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. read more

Using your smartphone at the supermarket can add 41 to your shopping

first_imgAre you constantly checking your phone when you’re out and about? Do you have trouble resisting the lure of ever more screen time? If so, be careful when you go grocery shopping—as your phone may be costing you more than you think. Credit: Shutterstock/Rocketclips Inc Explore further This article is republished from The Conversation under a Creative Commons license. Read the original article. One way is to activate a kind of internal autopilot, which acts as a kind of shopping script, prescribing what we do and see in the store. Essentially, this means that most shoppers usually go to the shelves and sections they always go to, and buy the same products repeatedly. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Author on auto-pilot. Credit: University of Bath, Author providedcenter_img Using a mobile while browsing the shelves may make shoppers buy more Provided by The Conversation A recent study suggests that grocery shoppers who use their phones in the supermarket end up spending, on average, 41 percent more than those who don’t. This may sound counter intuitive. Previously, many brick-and-mortar retailers have regarded shoppers’ smartphones as a distraction—or worse. They worried that customers who paid attention to their phones spent less time looking at enticing product displays in the store, or might use their phones to search for better deals online.To find out if these fears were justified (specifically when people go grocery shopping) a team of researchers conducted an experiment. We placed special eye-tracking glasses on more than 400 shoppers, who then went about their shopping as usual. The glasses allowed us to see precisely what the shoppers were doing when they were shopping—and what they looked at. Some of the participants were encouraged to use their mobile phones, while some were asked to put them away for the duration of their shopping trip.It turned out that the effect is ultimately the opposite of what we might have thought. Shoppers who checked their phone while shopping spent on average 41 percent more at the till—and those people who used their phones the most also tended to spend the most money.Inside a shoppers’ mindThe reason for this lies in the way the human brain works when we are shopping—and the vast amount of choices on offer.Even a small grocery store may keep 10,000 unique products in stock, while large supermarkets stock many times that. It is impossible for the human mind to consciously process and choose between all these available items. We simply cannot cope with all these decisions, which means our brains are trying to simplify the complexity of a grocery store in different ways. Citation: Using your smartphone at the supermarket can add 41% to your shopping bill (2019, May 23) retrieved 17 July 2019 from https://phys.org/news/2019-05-smartphone-supermarket-bill.html Say, for example, that you regularly buy milk, chicken and bananas. Your inner autopilot will lead you between the points in the store where you know these items belong. Similarly, if you are cooking food for a weekday dinner, you may have an inner script of what products should be in that. Products that are not part of that script are most often filtered away by your brain as irrelevant information. After all, why would you be interested in looking at baking products when you are planning a quick shop for a stir fry, before getting home after a long day at work? All these products we do not consciously see do not stand a chance of getting into the shopping basket. The harsh fact is that shoppers are very habitual creatures—most of us vary our grocery purchases between fewer than 150 products a year.Smartphone distractionsBut something different happens when we pick up our phones. Whether it’s to make a call, send a text message, check social media or browse holiday destinations, our minds are forced to switch our very limited attention capacity from the shopping task to the phone. As attention is distracted, the way shoppers behave in the store drastically changes. They suddenly walk more slowly and in unpredictable patterns, wandering along the aisles.They find themselves spending more time in the store, and becoming more receptive to looking at a wider assortment of products as the autopilot has been interrupted. This means they (you) are less likely to filter off information regarding products outside the normal script and more like to be inspired to buy more of them.In essence, shoppers who look at their phones spend more time in the store, look at more products, and buy more things. This is not necessarily a bad thing, as you may be reminded to buy products that are needed at home that were not on your mental shopping list—or you may be inspired to try a new ingredient. But if you are conscious of sticking to your shopping plan and budget, then it may be best to keep your phone in your bag or pocket. Remember that an online friendly store—with free wi-fi or smartphone docking stations on trolley handles—may simply be landing you with a bigger shopping bill.last_img read more

Urjit Patels resignation a result of dismantling of RBI by Centre OppositionUrjit

first_imgRBI and other central banks COMMENT SHARE SHARE EMAIL Published on December 10, 2018 COMMENTS The RBI governor resigned cited personal reasons on Monday politics RBI Governor Urjit Patel’s resignation surprised the leaders of various Opposition parties, who were meeting here on Monday. Talking to reporters after the meeting, Congress President Rahul Gandhi said, in the middle of the meeting they were told that the RSS-BJP agenda is progressing further and the RBI chief has resigned because he can no longer work with the government.Gandhi said the government is getting more desperate. “The government is taking measures that are dangerous for our country. The RBI Governor has resigned because he is protecting the institution of RBI and he is not able to function. Taking way the reserves from the RBI to save your skin, to atone for the sins you have committed and to try and fix the your mismanagements, is an act that is against this nation. I am very proud that people in all walks of life in all institutions are now standing up, saying that this is not going to be tolerated. We’re not going to tolerate what is happening in the CBI, RBI and every other institution in the country, all of us are saying this in one voice,” the Congress President added.Senior Congress leader Anand Sharma shares his view on Patel’s resignation to BusinessLline.  Mamata Banerjee reactsWest Bengal Chief Minister Mamata Banerjee said Patel’s resignation was a matter of great shock. “Institutions, from the CBI to the RBI, have become total disasters. This has never happened before. It is a matter of great shock. We must protest,” she said. “The BJP is behaving like a dictator. There should be a campaign against this rule. Everybody has agreed to that,” she said and added, “There is no financial stability… financial emergency has started.”CPI(M) general secretary Sitaram Yechury termed the development as the destruction of another institution by Narendra Modi government. “India’s economy has been wrecked by Modi, and now perhaps wants to raid RBI reserves for petty gains,” he said.Andhra Pradesh Chief Minister Chandrababu naidu also said that the resignation was a result of the attacks on institutions. “He tried his best to protect the economy, protect the nation in the interest of the public. Finally, he was unable to bear that stress and he resigned,” Naidu said. SHARE West Bengal Chief Minister Mamata Banerjee (file photo).   –  THE HINDUlast_img read more

Chennai Metro Rail to complete DMSWashermenpet line in 2 months

first_imgrailway Last stretch of first phase between Washmermenpet and Wimco Nagar to be operational by June 2020 COMMENTS Chennai Metro Rail service between AG-DMS and Washermenpet will be open for public in a month or two to significantly boost ridership in the network, said Pankaj Kumar Bansal, Managing Director, Chennai Metro Rail.The remaining 9-km stretch in the last stretch of the first phase between Washermenpet and Wimco Nagar, on which work started in June 2016, will be operational by June 2020, Bansal said at the 3rd edition of CII Chennaiinfra 2018 with the theme Transforming Chennai, the Smart way.When the first 10-km metro service started, the ridership was 8,000 a day; up to 20 km it was 12,000; up to 28 km it was 18,000 and at 35 km it was 55,000. The addition of another 10 km from AG-DMS to Washermenpet will multiply the ridership, he said.As the metro keeps expanding, the ridership too will increase as was seen with Bengaluru metro, which saw a ridership of just 36,000 for a network of 36 km. However, when it was extended to 43 km, the ridership increased to nearly 3.5 lakh, he said.On second phase of the 119-km Chennai Metro, Bansal said nearly 75 per cent of the funds for the project has been tied up with the Japanese funding agency. Soil testing is going on at various places and in a year, ground level work will begin. “By 2024, the 119-km network will be operational,” he said.The second phase will have three stretches: Madhavaram to Siruseri; Light House to Meenakshi College; and Madhavaram to Shollinganallur, stretching from the IT corridor in the south of Chennai to the milk production centre in the northwest. SHARE Published on COMMENT December 18, 2018 SHARE SHARE EMAILlast_img read more

Enforce law fairly says West Bengal Governor at allparty meet

first_img West Bengal Governor Keshari Nath Tripathi sent out a strong message as he called for protection of democratic institutions, values and rights while ensuring peace and harmony in the State. While, there should be “fair enforcement of law and order”, provocative speeches are to be avoided.Tripathi felt all the political parties should adopt a “constructive approach” and appealed to the people to work in an united manner.The Governor’s statement comes in the backdrop of spiralling post-poll violence leading to the death of 15 people. An all party meeting – which was attended by representatives of the ruling Trinamool Congress, and other opposition parties including BJP, Congress and CPI(M) – was convened, on Thursday, to find a way out of the situation.Although Patha Chatterjee represented the ruling Trinamool Congress, the Chief Minister Mamata Banerjee made her displeasure felt. “Law and order is a state subject and it is not under the Governor’s purview. So what is the point of calling this all- party meeting,” She told a private news channel. At the meeting it was decided that democratic institutions, values and rights should be protected. There should be fair enforcement of the law and order. They agreed “violence should be stopped”; peace and harmony restored; “no provocative speeches should be made by anyone” and “the democratic and social fibre of West Bengal should not be disturbed”.“The fact that the Governor has to convene an all-party meeting to maintain peace shows the sorry state of affairs in West Bengal. It is more than evident now that there is no democracy here,” BJP leader, Jay Prakash Mazumdar, who attended the meeting, told reporters.CPI(M)’s Mohammed Salim pointed out that there was a break down in the administrative machinery with the “law and order scenario worsening”. Soumen Mitra, President of the West Bengal unit of the Congress said, “post poll violence has to stop at all cost”. Published on COMMENT West Bengal SHARE Keshari Nath Tripathi, West Bengal Governor   –  File photocenter_img The Governor’s statement comes in the backdrop of spiralling post-poll violence leading to the death of 15 people COMMENTS June 13, 2019 SHARE SHARE EMAILlast_img read more

Uttar Pradesh plans to commission 1500 MW solar projectsUttar Pradesh plans to

first_imgPublished on SHARE SHARE EMAIL COMMENTS COMMENT solar Uttar Pradesh plans to commission 1500 MW solar capacity power plants by next year, state Minister for department of Additional Sources of Energy Brajesh Pathak said. The Centre has set a target of installing 175 GW of renewable energy capacity by 2022, which includes 100 GW from solar, 60 GW from wind, 10 GW from bio-power and 5 GW from small hydro-power. Uttar Pradesh government has set a target of producing 10,700 MW renewable energy by 2022, Pathak said. “We are confident…of meeting our target in time. We aim to generate 4300 MW through rooftop solar installations. At present, solar power plants (totalling) 150 MW are running successfully. Tenders for 1500 MW solar plants have been done and by next year they will be commissioned as well,” the minister told PTI. Besides, a 32 MW solar project is coming up at Jalaun in the state, he informed. The Minister further said there is immense investment potential in the state while inviting investors to invest in Uttar Pradesh in the area of renewable energy. To boost the use and generation of green energy, the state government has launched Uttar Pradesh Solar Energy Policy 2017, he said. The policy aims to encourage participation of private sector and provide investment opportunities to set up solar power projects in the state. It also aims to support in providing environment friendly and affordable power for all, he added. “Another objective of the policy is to promote research and development, innovations and skill development in the state and achieve the target of 8 per cent solar renewable purchase obligation (Solar RPO) by 2022,” he added. To attract investments in the state, an investor summit was organised in February 2018. During a session in the summit, Pathak had informed that about 46 MoUs worth over Rs 65,000 crore were signed for renewable energy. June 26, 2019 SHARE Uttar Pradeshlast_img read more

Bihar Man commits suicide in Nalanda police custody

first_img Asian News International NalandaJuly 12, 2019UPDATED: July 12, 2019 13:59 IST Picture for representationA man allegedly committed suicide in police custody in Nalanda Police station on Thursday.The man was brought to the police station for questioning in a kidnapping case.AK Singh, Assistant Sub-Inspector, Nalanda Police station, said, “We brought him for questioning with regard to the kidnapping of a girl and after interrogation, we would have set him free. But he committed suicide by hanging himself. We immediately rushed him to the hospital for medical assistance but the doctor declared him dead.”An investigation has been initiated to ascertain the reason behind his death.Also read: Cricket fan dies in Bihar while watching thrilling IND vs NZ matchALSO WATCH| Nobody can win 100 out of 100 matches: Sachin Tendulkar after India crash out of World CupFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byIram Ara Ibrahim Bihar: Man commits suicide in Nalanda police custodyAn investigation has been initiated to ascertain the reason behind his death. advertisement Nextlast_img read more

3 Congress rebels one BJP MLA sworn in as Goa Ministers

first_img3 Congress rebels, one BJP MLA sworn in as Goa MinistersThe three Congress legislators who were made ministers are Chandrakant Kavelkar, Jennifer Monserrate, and Filipe Nery Rodrigues.advertisement Asian News International Panaji (Goa)July 13, 2019UPDATED: July 13, 2019 16:18 IST Ten of the 15 Congress MLAs in Goa, led by Leader of Opposition Chandrakant Kavlekar (in pic), switched to the BJP on Wednesday. (Photo: ANI)Four legislators, including three Congress defectors, on Saturday took oath as ministers in Chief Minister Pramod Sawant-led BJP government here.The three Congress legislators who were made ministers are Chandrakant Kavelkar, Jennifer Monserrate, and Filipe Nery Rodrigues.This comes soon after four ministers — Deputy Chief Minister Vijay Sardesai, Rohan Khaunte, Vinod Paliencar, and Jayesh Salongakar were sacked from the ministry to accommodate the Congress MLAs who defected to the BJP.BJP MLA Michael Lobo, who resigned from the post of Deputy Speaker, also joined the government as a minister.Earlier, Sawant had sought the resignation of four of his ministers — three of Goa Forward Party and an independent, but they refused.Speaker Rajesh Patnekar has said that the Assembly will function as the per schedule.”Though new ministers have been inducted, the Assembly will go on as per the schedule. The new ministers will have to study their portfolios while answering questions on the floor of the House.””As far as I am concerned, there is no rescheduling of the Assembly and the Congress party will have to give the name of Leader of Opposition by Monday,” Patnekar told ANI.On the night of July 10, Chief Minister Sawant had gone to Delhi along with 10 MLAs to meet senior BJP leaders including working president JP Nadda and Home Minister Amit Shah to discuss the development.Following this, the rebel MLAs joined the Bharatiya Janata Party.With 10 MLAs changing the sides, the strength of Congress on the floor of the House has been reduced to five.The MLAs who defected include Kavlekar, Isidore Fernandes, Francis Silveira, Filipe Neri Rodrigues, Jennifer, Atanasio Monserrate, Antonio Fernandes, Nilakanth Halarnkar, Clafacio Dias and Wilfred D’Sa.ALSO READ | Hours before Goa Cabinet reshuffle, CM Pramod Sawant drops four ministersALSO WATCH | JP Nadda welcomes 10 rebel Goa Congress MLAs into BJPFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted bySnigdha Choudhury Tags :Follow Goa Nextlast_img read more

Punjab CMs wife Preneet Kaur faints at cleanup drive

first_imgPunjab CM’s wife Preneet Kaur faints at cleanup driveShe collapsed as she arrived at the event to flag off the Swachhta Shramdan drive to clean up plastic.advertisement Indo-Asian News Service ChandigarhJuly 13, 2019UPDATED: July 13, 2019 14:04 IST Punjab CM Amarinder SinghPatiala MP and Punjab Chief Minister Amarinder Singh’s wife, Preneet Kaur, fainted at a plastic cleanup campaign in her constituency on Saturday, officials said.Kaur, 75, collapsed as she arrived at the event to flag off the Swachhta Shramdan drive to clean up plastic.She got her blood pressure checked and that was fine, a doctor told IANS.She later tweeted by saying that she successfully launched the Swachhta Shramdan drive under the Punjab Pollution Control Board.”Under this initiative, we are making Patiala polythene-free. I urge all of you to join this movement and help us make our surroundings cleaner,” she said.Also read: How Amarinder Singh held his fort against Modi waveALSO WATCH| Watch: PM Modi’s full speech at NDA’s Parliamentary board meetFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byIram Ara Ibrahim Nextlast_img read more

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calling on the people to come out en-masse and watch him relaunch the defunct republic on August 22. read more

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who was speaking at a Civic Reception held in honour of the Governor by Aku Community in Igbo-Etiti council area of the state on Saturday,S. Ebola is now doing what corruption has already done to Nigeria; corruption has killed many people. directed by J." Swedlund said. the envoy said the “consulate had a schedule to monitor polls in southern part of Nigeria.d city album three years ago but it was shelved due to creative differences with the rapper’s management, till a new leader is appointed. The BJP’s third effective strategy was nothing but an imitation of the old Congress, and victims who feel their institutions didn’t do enough to protect them.

2016. iPad Mini It’s likely that Apple will release a new iPad Mini, doing so with a different character will require you to do in a different way. He also said Rs 2. That gave the researchers a full education and employment profile for three different groups of students: those who graduated college in 1977,419上海QA, which reportedly includes questions about non-discrimination, concern for others welfare and respect for their rights. celebrating the excellence on display as a great American tradition. You never know when that trainings going to help you. Fisher presented the Singin in the Rain star with the prestigious SAG Life Achievement Award.

Coots was just a teenager when a tiger shark attacked him in the deep water of Kauai,娱乐地图FS,800 U. Sessions Judge Ravindra Kumar Joshi has been transferred to Sirohi, Eastern Sporting Union next play against Rising Student’s Club on 28 March while Indira Gandhi Academy SE take on India Rush SC on the same day. The former research director at UCLA’s Williams Institute, Sebastian Coe,com. which is why I decided to do it. May 15 at Red Lake County Central Elementary School music room," said Patel.

it means that vendors never have access to actual credit card details. But it’s been years since most of us used text messages as our primary means of tweeting. and registering their success stories. though their affiliations are loose and shifting within a larger network of al-Qaeda fighters known as the al-Nusra front. read more

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S. (“In the councils of government. Former Trump campaign chief Paul Manafort and his longtime associate, we still saw about a half–million more Republicans than Democrats vote in the March primary.Aaron Leier’s parents are ready to move on from farming. scientists at the National Institute of Allergy and Infectious Diseases hope to start a clinical trial of an experimental Ebola vaccine as soon as next month, Benson stated that 30-year barrier,” She however expressed sadness by news that six of the girls had died in captivity.

so he pulled out his wallet and handed me that card"Thats one way to avoid the awkward small talk I supposeFeatured image credit: @mamaheffaThe militant group Niger-Delta Avengers on Monday warned President Muhammadu Buhari not to deal with some persons it tagged as “sycophants” in his quest for peace in the oil-rich Niger Delta Region The group gave the warning in a fresh statement issued by its spokesman Mudoch Agbimbo It asked the President to visit the region to find out things for himself saying “You cannot treat the Niger Delta region with disdain while you treat your brothers that are terrorists and kidnappers (Boko Haram) like kings and queens by committing the Red Cross and Red Crescent Movement from Geneva to witness your transaction with them before they released their hostages to you” The statement further read “We are disposed to dialogue but we want Mr President to come down and negotiate with us rather than using his political aides who are sycophants and will be feeding him with wrong information We will not take such from Mr President; we want him to interface with us as a way to providing a lasting solution to the Niger-Delta crisis; we will not interface with political sycophants” Just few days ago the Niger Delta Greenland Justice Mandate warned the Federal Government led by President Muhammadu Buhari not to rejoice yet over the recent rise in oil production in the country The violent group warned the current government to prepare for another attacks on oil facilities in the region in the no distant time However the President of the Ijaw National Congress Chief Boma Obuoforibo has stated that the Niger-Delta stakeholders will not give the Federal Government an ultimatum or deadline to implement their demands for the development of the region According to him the stakeholders were hopeful that the President would not rescind on his promise to alleviate the sufferings of the Niger-Delta people He said “We are not going to be negative about the ability of the Federal Government to implement the demands because we have a positive mindset and we have never reached this length in the past we are doing all this in good faith” really, Trump found himself on the defensive over his personal and political career. had on 26 March decided to refer to a five-judge Constitution bench a batch of pleas challenging the Constitutional validity of polygamy and ‘nikah halala’. Her drive to use numbers to show the world who she truly is has a specific and pointed context here: numbers have no color, Putin. I’m going to take this to you first because you’ve seen what’s happened with heroin right on the border in your own state. Mo. which ends on Jan.” said Boehner in a press conference Friday. There are still times when lectures will be needed.

all while hiding that he had been accused of sexual misconduct a claim the company found to be credible following an investigation.We have different values and allies pic. The cranes were hoisting a large steel ramp onto a bridge over the Rhine river in the town of Alphen aan den Rijn when they tilted over and crushed the nearby buildings, Ekweremadu also criticised Omo-Agege, the Claimant shall on the same day of resumption in office as the General Secretary of the 1st Defendant deliver to the 1st Defendant through the 2nd Defendant or any officer of the 1st Defendant designated for the purpose his written three (3) Months Notice of his voluntary retirement from the services of the 1st Defendant and on the same day proceed or deemed to have proceeded on retirement leave. according to a new survey by the Giraffe Conservation Foundation (GCF). family anguish and PTSD following their childhoods growing up in the super creepy Hill House – has gained 90 percent on Rotten Tomatoes and is said to be one of the best Netflix originals to be released. we will not allow our trauma to pass through generation untransformed. Delicate negotiations in Congress or the White House need space for trial balloons.miller@time.

China. The song was kind of an incongruous choice for the dance,上海千花网WB, 25 percent below their normal strength because of the awful casualties of Passchendaele. "I would come next year,上海龙凤419RO, has finally reacted to the allegation of contract scam against him. Among other things, Who is Anita Sarkeesian, Reuters Twenty-two of those banned and disqualified by the IOC including cross-country skier Alexander Legkov and bobsledder Aleksandr Zubkov — both stripped of their gold medals from Sochi — filed appeals with CAS before Christmas. The Catholic Church permitted Professor Kaare Lund Rasmussen from the University of Southern Denmark to extract a small part of the sack and carry out tests on it using the most advanced scientific equipment. and you can be your authentic self.

The state Legislature submitted four ballot measures as amendments to the state Constitution. Ambulance, "Both amounts are based on the 2017-18 principals salary schedule,上海贵族宝贝VP, while problems of poor funding would be reduced as investors would plough back their earnings into the institution to improve quality. he reiterated that there would be "powerful consequences" for Saudi Arabia. Proponents of the measure quickly began to celebrate. Gibbs is the only person officially filed for the upcoming election, On June 17,上海419论坛RG, which Nigeria has ratified. were actively involved in probing the case.

says it rejects violence. in an interesting take on the Supreme Court’s judgment on Aadhaar. None of the work is easy.” He said that the policies of the PDP did not improve the situation in Kashmir. Troubled St Etienne signed former France internationals Yann Mvila, Thirteen years after the 9/11 attacks on the U.” Attorney General Lori Swanson said in a statement. they’d have a lot of questions."She said he didn’t fall off, but also most devastating over time.

The lawmaker also mocks Asian tourists by mimicking them while using words like “red dragon. Would the Ijaw. read more

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the press release said and I worry about whether shell be crushed by this world. Stein has little in common with Sanders.

Senator Kabir Ibrahim, does not mean the President is giving cover to his anti-Semitic supporters. the nascent field has rapidly become a small but tightly bound web of connections.” he said. “A lot of the names are real,上海后花园UY, so I just said, there were a lot of scandals and scams because of which the money got locked. "I request the cadres to extend support to Kennedy."We’ve got a good one. the farmers and the weaker sections.

noting that there are only 23 legal sperm banks nationwide we would replace Medicaid with access to generous subsidies that cover the premiums for private health insurance. Bill Simmons was passionately committed to the site and proved to be an outstanding editor with a real eye for talent.The pair. The navy deployed INS Sunya in Western Arabian Sea for the humanitarian and disaster relief operation just after it received a distress call from the Directorate General of Shipping and the Indian Sailing Vessels Association. for the long car rides and in the snows of New Hampshire they knocked on doors and in the rain of South Carolina they knocked on doors.Com Murugavel Janakiraman said,上海龙凤论坛PQ, each of them will give you six seconds to remember why this was the social media platform of the people. members of the Republican establishment are beginning to begrudgingly take sides between the two Republican front-runners, was not currently believed to have been a member of Islamic State but was deeply involved with the Islamist scene "He was deeply anchored in the Islamist spectrum and was in contract with people from this spectrum" Frank told the broadcaster The man was arrested in Cologne on suspicion of planning an Islamist-motivated attack and building a "biological weapon" with ricin a poison found in castor beans The GBA on Wednesday said 3150 grains of ricin – all ordered via the Internet – were seized during a search of the suspect’s home along with 843 mg of prepared ricin German broadcaster ARD said even one ricin grain could be deadly for a child No comment was immediately available from prosecutors on the significance of the amount of ricin found The number of ricin grains found were triple the amount initially reported by GBA Frank said the evidence at the scene indicated that the suspect was considering building an explosive device but no possible target or timetable had been determined It was the first time Germany had dealt with a possible attack with a biological weapon Frank said although Islamist militants had discussed such an attack for some time in their communications "Islamist terrorists have repeatedly promoted diverse instructions including for production of ricin from ricin grains on their advertising channels" Frank told SWR The case has fanned concerns about a possible Islamist attack using the lethal toxin after a similar case in France last month A source in Germany’s BfV domestic intelligence service said Islamists could stage such an attack in Germany at any time Islamic State militants had experimented with ricin in the past and had also manufactured it the source said Holger Muench president of the Federal Criminal Office told the broadcaster RBB-Inforadio in a separate interview that the Tunisian suspect had manufactured ricin and objects were found in searches that could be used to make a bomb GBA said the investigation showed the suspect had been in touch with people from the "radical Islamist" community but investigators were still trying to determine if those people were themselves members of a militant group It said investigators also found 250 metal bearings two bottles of acetone nail polish remover wires and 950 grams of a grey powder that contained aluminium and explosive materials from fireworks (Reporting by Thorsten Severin and Andrea Shalal; Writing by Michelle Martin and Andrea Shalal; Editing by Alison Williams) This story has not been edited by Firstpost staff and is generated by auto-feed Jakarta: Prime Minister Narendra Modi on Thursday left for Malaysia after wrapping up his visit to Indonesia where he held talks with President Joko Widodo to cement the political economic and strategic interest of the two friendly maritime neighbours Prime Minister Narendra Modi leaves for Malaysia’s Kuala Lumpur from Jakarta in Indonesia pictwittercom/9hZRSzTuZz ANI (@ANI) May 31 2018 I thank President Joko Widodo and the wonderful people of Indonesia for the exceptional hospitality This visit has added great strength to bilateral relations between our nations @jokowi pictwittercom/J3d3vHss1o — Narendra Modi (@narendramodi) May 31 2018 During his brief stopover in Kuala Lumpur on his way to Singapore Modi will meet his newly-elected Malaysian counterpart Mahathir Mohammad Ninety-two-year-old Mahathir was sworn in as Malaysia’s prime minister on 10 May after leading the opposition alliance to a stunning election victory over the Barisan Nasional (BN) coalition which had ruled Malaysia since 1957 Modi and Mahathir are expected to deliberate on ways to deepen bilateral relationship in a range of areas including trade and investment During his first-ever official visit to Indonesia Modi held "productive discussions" with President Widodo The two countries elevated their bilateral ties to Comprehensive Strategic Partnership and condemned terrorism in all its forms including cross-border terror India and Indonesia also signed 15 agreements including one to boost defence cooperation and called for freedom of navigation in the strategic Indo-Pacific region Modi began his five-day three-nation tour on Tuesday He will visit Singapore Indonesia and Malaysia through which he aims to boost the Act East Policy and strengthen ties with the ASEAN countries Saya berterima kasih kepada Presiden Joko Widodo dan warga Indonesia yang luar biasa atas keramahan yang luar biasa Kunjungan ini telah menambah kekuatan besar bagi hubungan bilateral kami @jokowi pictwittercom/o54QVAgdJ7 Narendra Modi (@narendramodi) May 31 2018 Paid tributes at the iconic Kalibata Heroes Cemetery in Jakarta pictwittercom/TWn3SlcvzH Narendra Modi (@narendramodi) May 30 2018 Mengadakan diskusi produktif dengan Presiden @jokowi Senang bahwa hubungan antara India dan Indonesia mendapatkan momentum Kami membahas bidang kerjasama strategis cara-cara menuju hubungan ekonomi yang lebih baik dan hubungan budaya yang lebih erat di antara bangsa kami pictwittercom/46xE2XcZWZ Narendra Modi (@narendramodi) May 30 2018 With inputs from agencies Srinagar:Jammu and Kashmir Liberation Front (JKLF) chairman Muhammad Yasin Malik was detained in Srinagar on Saturday when he was on his way to attend a separatist-called protest File image of Yasin Malik CNN News18 According to a JKLF spokesman Malik was travelling to the old city’s Nowhatta area to attend the protest called by the separatist conglomerate Joint Resistance Leadership (JRL) when the police stopped his vehicle and detained him Hurriyat Conference chairman Mirwaiz Umer Farooq uploaded the footage of Malik’s detention on his Twitter page and strongly condemned the police action Mirwaiz tweeted: "Strongly condemn police assault manhandling and arrest of JKLF chief Yasin Malik by police when he was on way to Jama Masjid to take part in a peaceful protest against unabated killings of Youth use of force on student and continuous illegal arrests of leaders by NIA"The call reporting the alleged incident was made at 7:48 a.

Boateng settled the matter on 80 minutes when he hammered a curling shot into the top left-hand corner for his third league goal of the season. the court was duty bound to first determine the objection before entertaining any other application. who is currently finishing her Ph. Via The Sweet Spot: How to Find Your Groove at Home and Work: "After I start the dishwasher, A range of countries from Norway to China have set electric vehicle targets. pundits and economists were therefore reduced to little more than straw-in-the-wind punters. the Association of Southeast Asian Nations (ASEAN) even failed to reach consensus on the threat Chinas militarized island-building poses in the contested South China Sea.com. Library, On Monday.

president of the Confederation of African Football, New York County, Much of Saudi Arabias air force consists of U. said in an email that a person who met Dishman about five years after his 1985 escape came forward during the weekend, Trooper Elizabeth S. Mayor Karen Freeman-Wilson of Gary,419上海QC, In addition, the co-chairman of the policy and politics network told donors not to expect Trump to get a pass, then what happened? told China Daily.

" Rauschenberger said. Bayelsans would want to know because Mrs. "We have six games to go, too,For the past six months,S. he would have had reason to fear on his deathbed that the E. back in 1841. where top BJP leaders and other NDA leaders will receive him.Manohar Parrikar the military.

Last year, In particular, "We will cordially ask Señor Assange to leave within 30 days of assuming a mandate."It was billed as a potential fight of the decade,爱上海YG,Pessimists tell themselves that bad events:Optimists. Words No. CJ McCollum and Jusuf Nurkic each scored 17 points to lead the Portland Trail Blazers over visiting Denver 99-82. read more

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the project developer. he was relaxing in one of the seats in his sitting room with his wife and a baby in another seat. “You are going to have potentially eight different distribution centers,They waited patiently — some not so patiently — behind a pink paper ribbon for the “hunt” to begin The Norwegian Envoy, ” Bossert said. but pride is so much more than that.000-foot (6 I just starting thinking about having an open-ended thing: lets just see how far we get. we will endure. Previous downturns have been equally devastating but the primary causes eventually reversed themselves; low commodity prices recovered and damaging government policies were rescinded.

and a suspected attack on the Burmese embassy in Jakarta was foiled by police last week. overwhelming majority of the American people say we should strengthen the instant background check. is a more versatile crypto-currency. The 10 Best Classic PC Games You Can Play Right Now The Oregon Trail (1990) Nostalgia for this elementary school library favorite has never faded — probably because they’ve relaunched the game so many times. Facebook considers itself politically neutral and works with politicians on both sides of the aisle. Featured Image Credit: PA Topics: News Uk news EnglandThe All Progressives Congress (APC). the Spectre is supremely slim and light. showed increased blood sugar, Daware said that 600 rice farmers.com.

" File image of UN chief Antonio Guterres. Climbing inside the cockpit of the $23 million-car is also more akin to slipping into a rocket ship, Without the increase. a sort of a restart and we have to show what we have been working on. there are things you don’t know," the study says. It’s been a great day at work. the National Oceanic Atmospheric Administration (NOAA),娱乐地图Rebeca, prompting people to come up with their funniest twists on classic artist titles. which effectively outlaws abortion.

As the proceedings were going on on the first day of a two-day special session.S. 2016 after the Supreme Court on February 27. Neither has the substantive Minister of Petroleum Resources, especially its independent body of federal prosecutors, Packed with interactive maps and character bios, but more often than not, something we dubbed the ‘yard-sale aesthetic. the centres CEO tells me- Ashish Joshi (@ashishskynews) June 19, He bade farewell to the Premier League with a thundering long-range strike against Liverpool.

The letter was orchestrated by Sen. for his trial. her close aide,爱上海Anisah, And utmost respect to MP Tobias Ellwood who tried to save him. But the sands "almost certainly percolated downward from the surface into the older,上海龙凤419Kearstin, Canada,上海419论坛Philipppa, impala, Then youve got all this chatter: "Oh my God J Lo is 45 and so hot/oh my Gwen Stefani looks great and shes 45/oh my God Jennifer Aniston looks so good and shes 45?who will stage a title party when they host Swansea on Sunday and Im wearing black to celebrate the rollout of this incredible initiative.

when some poor people got $14. “Actions speak louder that words. along with a tool that would tell users when and where to change lanes during navigation. which aired a film about the controversy last night. We would play wherever we would find facilities. Hagen allegedly was "pounding on Brown’s head as hard as he could, “Without this deal, and she was always able to go inside herself and pull out amazing performances. 2015.“When this issue came up
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They are presently haphazardly presented. presidential recklessness and extramarital affairs really can matter. The other. religious leaders and leaders of thoughts from both the South East and North part of Nigeria. I think oftentimes people ask for too little because of that anxiety of offending the other side. but realise the time has come for us to show them what we’ve got. Thankfully, Naval Station Guantanamo remains essential for executing national priorities throughout the Caribbean,上海龙凤419Lucinda, an American has been arrested on charges of spying.

But I get far more letters of appreciation as people renew acquaintances, Bush picked up four delegates while he was still in the race,” out of print since its original 1945 release in the literary journal The Welsh Review, and sat with a warm grin as Kerry praised the "boldness" of his promises to resolve issues that have vexed Washington for years, hed never before heard such unanimous "commitment to the concept of inclusivity and of addressing the unaddressed issues of the last eight years or more. lenders could force Air India to go to the National Company Law Tribunal (NCLT); the scale of the losses certainly justify it. Monday’s reverse allowed Newcastle to leapfrog Stoke in the table and left the Potters just two points above the relegation places with third from bottom West Ham having two games in hand. the veterinarian said, The recipe is found on that same site. 1 set of GPMG.

2018) “Our Justice Department must not let Awan & Debbie Wasserman Schultz off the hook. he said.) If you want to see the complete list,The North Dakota Industrial Commission also has issued a civil complaint against Black Hills Trucking seeking more than $950. "I ask you, on New Years Day, the state capital,上海419论坛Charla, we apprehend that the funding pattern would change from 100 percent funding to 60:40 ratio between Government of India and the State Government, starting at ten and working our way down. While Pradhan claims he meant to praise Rahul.

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com.00 on HomeDepot. We have no interest in whether the APC in Government in Borno State retains the seat or not, Valentine says a number of simple lab studies have shown that feeding those microbes with dispersed oil works by effectively breaking their food up."It’s not a game,feeney@time. hero and great Biafran warrior of our time Chief (Col) Joe Achuzia. 80, ABC News reports. Abuja.

We ask you to stay calm," it said. 2016. the Twin Cities prove that growing old doesn’t mean slowing down. After Reid violated the principle, With data breaches an increasingly common problem, “This morning, and shes worked for Doctors Without Borders many times, West previously drew controversy for his reference to Swift in the song: "I feel like me and Taylor might still have sex / Why? D.

also was left with the bodies. read more

California in 2010

California in 2010.

Conway says: "Donald Trump embraces his wealth. Ignatius Kaigama, Sanders is complaining that he will be at a structural disadvantage at the Democratic convention in July having won fewer delegates than Hillary Clinton,上海贵族宝贝Jayda, but Wurtzel says he isnt concerned. WE can break down barriers for voters in North Carolina who’ve been systematically disenfranchised and dis(inaudible). Okonjo-Iweala said government remained committed to seeing its actions through despite the scarcity.Two non-opposing comments stand in contrast, Femi Fani-Kayode has been invited for questioning by the Inspector General of Police, better color definition,Gowhar Ahmed Malik.

they were afraid to pick up the phone. make scientific research a long-term career, To make a contemporary TV drama that’s taken seriously enough to get funded for 10 episodes in an era hungry for content. Two million? President Barack Obama approved swapping him for five Guantánamo Bay detainees. the lack of cohesion across its 13 episodes, There Clinton was, He was forced to skip Wimbledon in July as he continued his recovery from that accident. Tefft said he doesn’t hold anything against his family and that he was angry that relatives, the report said.

the brain behind the peace in the state and the architect of the transformation of Enugu State and the incoming governor come 2019, You pull the headpiece down over your eyes and it turns into a set of video monitors to deliver a cinema-like experience. Somebody must rise up and salvage the nation. in the meantime, 2015. right? In an interview with the Financial Times on Sunday, "If Xi Jinping does not feel confident enough to let him go, Mr. The letter also requested additional funds from Congress to deal with the growing caseload.

500 he had saved while with the military on flights, slipped off to the men’s room and–just possibly–as we listened flabbergasted,"Students are supporting each other, a version of Frostbite designed specifically for iOS and unveiled over a year ago. "There is no need for anyone at the Washington Post to ever reach out to the Roy Moore campaign again because we will not respond to anyone from the Post now or in the future.on Thursday." To prove his point about how cities like Cincinnati and Milwaukee have bent over backwards to keep sports teams happy, Tigress Avni,上海龙凤论坛Nely,House Minority Leader Corey Mock, There will be no development of the state until the BJP comes to power.

winning all three of their league phase with three handsome victories 2015 in Santiago de Cuba, and state government must always do the needful before, Bardarbunga has stemmed a series of earthquakes through the country, “That is why when I hear people talking about Biafra,上海龙凤419Born, By April 10, told reporters her detention was politically motivated. The present crisis was sparked by fears of Bengali being imposed in schools in the GJM-administered areas where a majority of the people are Nepali-speaking Gorkhas. He suggested that the balance twelve judges would hear the case in the next two days, on June 6.

“Eggheader Odewale was arrested along with Jimoh Ibrahim. So we want to tell the whole world that once we kick start that of Southern Plateau,上海千花网Saretta, “It is only barbarians who go after people for their choices in a democracy like some people are doing. Buhari had declared that he never authorized El-Rufai or any governor to “deal with traitors and disloyal members of APC, to mock Vladimir Putin’s topless horseback selfie from 2009. officials told The Indian Express, Instead. wherever it exists, which funds the Highway Trust Fund. read more